126 research outputs found
DESIGN OF THREE FINGER GRIPPER WITH FSR
Get PDFTechnological advancement is widening up by the advent of new inventions. Robots are going to be an integral part of the completely automated industries. There are many instances where profile detection. In this paper, discussed about the three finger gripper has the abilities with this dexterous electric gripper. Three fingers gripper is extreme changeability and fixable gripping control. Its finger has several positions of geometrics and dimensions. Its specific control of crossing point allows orthodox forward motion on the finger location, rapidity and force. These fingers design in CREO 3.0 software and produced by RPT. Fingers are evaluated to check if the finger is flexible motion. The force is measured by a force sensitive resister (FSR). A force sensor is measure a grasping object whose confrontation difference between before and after force is applied. The Arduino mega controller is used for controlling the servo motor and FSR in gripping motion. This servo motor is 180Ëšrotation angle, Control loop response mechanism is extensively used for accurate control. The Controlled gripper finger is sensed and gripped with force which is being analyzed in the data
Semi-Distributed Demand Response Solutions for Smart Homes
Get PDFThe Internet of Things (IoT) paradigm brings an opportunity for advanced
Demand Response (DR) solutions. It enables visibility and control on the
various appliances that may consume, store or generate energy within a home. It
has been shown that a centralized control on the appliances of a set of
households leads to efficient DR mechanisms; unfortunately, such solutions
raise privacy and scalability issues. In this chapter we propose an approach
that deals with these issues. Specifically, we introduce a scalable two-levels
control system where a centralized controller allocates power to each house on
one side and, each household implements a DR local solution on the other side.
A limited feedback to the centralized controller allows to enhance the
performance with little impact on privacy. The solution is proposed for the
general framework of capacity markets
Pre-Harvest Application of a New Biocontrol Formulation Induces Resistance to Post-Harvest Anthracnose and Enhances Fruit Yield in Mango
Get PDFPre-harvest application of biocontrol formulations consisting of 1. the two plant growth promoting
rhizobacterial strains FP7 and Pf1 of Pseudomonas fluorescens; 2. a strain of Bacillus subtilis Bs-1; and 3. a strain
(Sc-1) of the yeast Saccharomyces cerevisiae, given at fortnightly or monthly intervals and with or without a chitin
amendment, were evaluated in two trials for their ability to reduce anthracnose in mango caused by Colletotrichum
gloeosporioides. Growth of C. gloeosporioides in vitro was significantly reduced by strain FP7 and in both field trials
the bacterial strain in combination with chitin significantly reduced infection. Pre-harvest application of these formulations
at fortnightly intervals also significantly improved flower initiation, yield parameters (mean number of
fruits and fruit yield) and fruit quality (total soluble solids, ascorbic acid, free acidity, total, reducing and non- reducing
sugar content). The delay in latent symptom expression increased by 15 days under stored conditions. The highest
levels of phenolic content, peroxidase and polyphenol oxidase on mango leaves, flowers and fruits were achieved
with FP7 +chitin
Body composition and body fat distribution are related to cardiac autonomic control in non-alcoholic fatty liver disease patients
Get PDFBACKGROUND/OBJECTIVES: Heart rate recovery (HRR), a cardiac autonomic control marker, was shown to be related to body composition (BC), yet this was not tested in non-alcoholic fatty liver disease (NAFLD) patients. The aim of this study was to determine if, and to what extent, markers of BC and body fat (BF) distribution are related to cardiac autonomic control in NAFLD patients. SUBJECTS/METHODS: BC was assessed with dual-energy X-ray absorptiometry in 28 NAFLD patients (19 men, 51±13 years, and 9 women, 47±13 years). BF depots ratios were calculated to assess BF distribution. Subjects’ HRR was recorded 1 (HRR1) and 2 min (HRR2) immediately after a maximum graded exercise test.
RESULTS: BC and BF distribution were related to HRR; particularly weight, trunk BF and trunk BF-to-appendicular BF ratio showed a negative relation with HRR1 (r 1⁄4 0.613, r 1⁄4 0.597 and r 1⁄4 0.547, respectively, Po0.01) and HRR2 (r 1⁄4 0.484, r 1⁄4 0.446, Po0.05, and r 1⁄4 0.590, Po0.01, respectively). Age seems to be related to both HRR1 and HRR2 except when controlled for BF distribution. The preferred model in multiple regression should include trunk BF-to-appendicular BF ratio and BF to predict HRR1 (r2 1⁄4 0.549; Po0.05), and trunk BF-to-appendicular BF ratio alone to predict HRR2 (r2 1⁄4 0.430; Po0.001).
CONCLUSIONS: BC and BF distribution were related to HRR in NAFLD patients. Trunk BF-to-appendicular BF ratio was the best independent predictor of HRR and therefore may be best related to cardiovascular increased risk, and possibly act as a mediator in age-related cardiac autonomic control variation.info:eu-repo/semantics/publishedVersio
The association of heart rate recovery immediately after exercise with coronary artery calcium: the coronary artery risk development in young adults study
Get PDFWe tested whether slower heart rate recovery (HRR) following graded exercise treadmill testing (GXT) was associated with the presence of coronary artery calcium (CAC). Participants (n = 2,648) ages 18–30 years at baseline examination underwent GXT, followed by CAC screening 15 years later. Slow HRR was not associated with higher odds of testing positive (yes/no) for CAC at year 15 (OR = 0.99, p = 0.91 per standard deviation change in HRR). Slow HRR in young adulthood is not associated with the presence of CAC at middle age
Usefulness and limitations of transthoracic echocardiography in heart transplantation recipients
Get PDFTransthoracic echocardiography is a primary non-invasive modality for investigation of heart transplant recipients. It is a versatile tool which provides comprehensive information about cardiac structure and function. Echocardiographic examinations can be easily performed at the bedside and serially repeated without any patient's discomfort. This review highlights the usefulness of Doppler echocardiography in the assessment of left ventricular and right ventricular systolic and diastolic function, of left ventricular mass, valvular heart disease, pulmonary arterial hypertension and pericardial effusion in heart transplant recipients. The main experiences performed by either standard Doppler echocardiography and new high-tech ultrasound technologies are summarised, pointing out advantages and limitations of the described techniques in diagnosing acute allograft rejection and cardiac graft vasculopathy. Despite the sustained efforts of echocardiographic technique in predicting the biopsy state, endocardial myocardial biopsies are still regarded as the gold standard for detection of acute allograft rejection. Conversely, stress echocardiography is able to identify accurately cardiac graft vasculopathy and has a recognised prognostic in this clinical setting. A normal stress-echo justifies postponement of invasive studies. Another use of transthoracic echocardiography is the monitorisation and the visualisation of the catheter during the performance of endomyocardial biopsy. Bedside stress echocardiography is even useful to select appropriately heart donors with brain death. The ultrasound monitoring is simple and effective for monitoring a safe performance of biopsy procedures
Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity
Get PDFOxidative stress plays a key role in the pathogenesis of cancer and many metabolic diseases; therefore, an effective antioxidant therapy would be of great importance in these circumstances. Nevertheless, convincing randomized clinical trials revealed that antioxidant supplementations were not associated with significant reduction in incidence of cancer, chronic diseases and all-cause mortality. As oxidation of essential molecules continues, it turns to nitro-oxidative stress because of the involvement of nitric oxide in pathogenesis processes. Peroxynitrite damages via several distinctive mechanisms; first, it has direct toxic effects on all biomolecules and causes lipid peroxidation, protein oxidation and DNA damage. The second mechanism involves the induction of several transcription factors leading to cytokine-induced chronic inflammation. Finally, it causes epigenetic perturbations that exaggerate nuclear factor kappa-B mediated inflammatory gene expression. Lessons-learned from the treatment of several chronic disorders including pulmonary diseases suggest that, chronic inflammation and glucocorticoid resistance are regulated by prolonged peroxynitrite production
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Get PDFReactive oxygen species (ROS) are cellular signals but also disease triggers; their relative excess (oxidative stress) or shortage (reductive stress) compared to reducing equivalents are potentially deleterious. This may explain why antioxidants fail to combat diseases that correlate with oxidative stress. Instead, targeting of disease-relevant enzymatic ROS sources that leaves physiological ROS signaling unaffected may be more beneficial. NADPH oxidases are the only known enzyme family with the sole function to produce ROS. Of the catalytic NADPH oxidase subunits (NOX), NOX4 is the most widely distributed isoform. We provide here a critical review of the currently available experimental tools to assess the role of NOX and especially NOX4, i.e. knock-out mice, siRNAs, antibodies, and pharmacological inhibitors. We then focus on the characterization of the small molecule NADPH oxidase inhibitor, VAS2870, in vitro and in vivo, its specificity, selectivity, and possible mechanism of action. Finally, we discuss the validation of NOX4 as a potential therapeutic target for indications including stroke, heart failure, and fibrosis
The enigma of in vivo oxidative stress assessment: isoprostanes as an emerging target
Get PDFOxidative stress is believed to be one of the major factors behind several acute and chronic diseases, and may also be associated with ageing. Excess formation of free radicals in miscellaneous body environment may originate from endogenous response to cell injury, but also from exposure to a number of exogenous toxins. When the antioxidant defence system is overwhelmed, this leads to cell damage. However, the measurement of free radicals or their endproducts is tricky, since these compounds are reactive and short lived, and have diverse characteristics. Specific evidence for the involvement of free radicals in pathological situations has been difficult to obtain, partly owing to shortcomings in earlier described methods for the measurement of oxidative stress. Isoprostanes, which are prostaglandin-like bioactive compounds synthesized in vivo from oxidation of arachidonic acid, independently of cyclooxygenases, are involved in many human diseases, and their measurement therefore offers a way to assess oxidative stress. Elevated levels of F2-isoprostanes have also been seen in the normal human pregnancy, but their physiological role has not yet been defined. Large amounts of bioactive F2-isoprostanes are excreted in the urine in normal basal situations, with a wide interindividual variation. Their exact role in the regulation of normal physiological functions, however, needs to be explored further. Current understanding suggests that measurement of F2-isoprostanes in body fluids provides a reliable analytical tool to study oxidative stress-related diseases and experimental inflammatory conditions, and also in the evaluation of various dietary antioxidants, as well as drugs with radical-scavenging properties. However, assessment of isoprostanes in plasma or urine does not necessarily reflect any specific tissue damage, nor does it provide information on the oxidation of lipids other than arachidonic acid
Mendelian randomization analyses in cardiometabolic disease:the challenge of rigorous interpretations of causality
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